cyclosporine monitoring in organ transplantation: do we need a new concept?

DDH Epidemiology Revisited: Do We Need New Strategies?

Background: Although the developmental dysplasia of the hip (DDH) is well known to pediatric orthopedists, its etiology has still remained unknown and despite dedication of a vast majority of research, the results are still inadequate and confusing. The exact incidence of DDH and its relationship with known risk factors in Iran is still unknown. Here we represent the results of one year study o...

Aortic stenosis severity: do we need a new concept?

Ramadan fasting: Do we need more evidence?

Over a billion of Muslims fast worldwide during Ramadan each year. Through this religious custom, fasting contributes to their health as well as their spiritual growth. However, available evidence regarding the health-benefits of Ramadan fasting is scarce and highly contentious. Although Islam exempts patients from fasting, many fast conceivably, and their clinical condition is prone to deterio...

Staff Burnout… Do we need any intervention?

Dear Editor, As you know physical and mental wellness of physicians and nurses, as the main role in the treatment of patients, in conditions such as burnout, compassion fatigue, depression, and poor work-life balance, is one of the top priorities in the U.S.A. National Academy of Medicine  (1-4). Although healthcare team members are generally known as a caregiver to others;  their h...

The significance of determining the therapeutic dose of cyclosporine-A in patients undergoing organ transplantation

Immunosuppressive drugs are now unavoidibly used after the transpantation of liver,heart and bone marrow, as well as in certain autoimmune diseases.among these agents,cyclosporine-A (CYA) is one of the most effective Immunosuppressants which is widely used.but as any Immunosuppressive agent,the use of CYA is not without harmful side effects.neurotoxin,nephrotoxic and hepatotoxic complications,m...

Do we need new autoantibodies in lupus?

Systemic lupus erythematosus (SLE) is a clinically and serologically complex disease that demonstrates clinical, epidemiological and genetic differences among racial and ethnic groups. Some autoantibodies are useful for diagnosis of the illness. Others are clinically important because of associations with a particular manifestation of SLE. Antibodies to RNA helicase A (anti-RHA) comprise a newl...